Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Bmi1)Aiwa}
• Allele Name: targeted mutation 1, Atsushi Iwama
• Allele ID: MGI:5496634
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Bmi1)Aiwa/Gt(ROSA)26Sor^+ Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5496651

Genotype
MGI:5496651

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Bmi1)Aiwa}/Gt(ROSA)26Sor⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:198331 )

N • mice exhibit normal steady state hematopoiesis and colony-forming capacity of hematopoietic stem and progenitor cells

increased hematopoietic stem cell number ( J:198331 )

• during serial transplantation

abnormal hematopoietic stem cell physiology ( J:198331 )

• hematopoietic stem cells exhibit enhanced expansion ex vivo and protection against loss of self-renewal capacity during serial transplantation compared with wild-type cells

• hematopoietic stem cells exhibit resistance to oxidative stress compared with wild-type cells

• however, no radioprotection is observed

increased hematopoietic stem cell proliferation ( J:198331 )

• during serial transplantation

cellular

increased hematopoietic stem cell proliferation ( J:198331 )

• during serial transplantation