Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Iaai mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(944 available)
|
|
|
hematopoietic system
|
• hematopoietic stem and progenitor cells (HSPCs) infected with MLL-AF9 and transplanted in lethally irradiated recipients treated with tamoxifen produce fewer white blood cells compared with control cells
• bone marrow HSPCs infected with MLL-AF9 or AML1-ETO and treated with tamoxifen exhibit reduced colony number and loss of blast colony morphology unlike control cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Iaai mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation
(6 available);
any
Ndor1 mutation
(32 available)
|
|
|
hematopoietic system
|
• total bone marrow cells transplanted in lethally irradiated recipients and treated with tamoxifen induce a low abundant transient wave of CD4/CD8 double-positive T cells without inducing acute T cell leukemia (T-ALL) compared with control cells
|