About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif5atm1.2Noh
targeted mutation 1.2, Nobutaka Hirokawa
MGI:5495650
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Kif5atm1.1Noh/Kif5atm1.2Noh involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA MGI:5495662
cn2
 		Kif5atm1.2Noh/Kif5atm1.2Noh
Tg(Syn1-cre)671Jxm/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA MGI:5495663


Genotype
MGI:5495662
ht1
Allelic
Composition		 Kif5atm1.1Noh/Kif5atm1.2Noh
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5atm1.1Noh mutation (0 available); any Kif5a mutation (54 available)
Kif5atm1.2Noh mutation (0 available); any Kif5a mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:197666 )
• mice exhibit normal appearance, body size, brain morphology and behavior




Genotype
MGI:5495663
cn2
Allelic
Composition		 Kif5atm1.2Noh/Kif5atm1.2Noh
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5atm1.2Noh mutation (0 available); any Kif5a mutation (54 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:197666 )
• mice die at approximately 3 weeks postnatally

nervous system
nervous system phenotype ( J:197666 )
N
• mice exhibit normal brain histology
seizures ( J:197666 )
• mice exhibit epileptic electroencephalography (EEG) and reduced EEG power during rest and locomotive states compared with control mice
abnormal GABA-mediated receptor currents ( J:197666 )
• impaired neurotransmission in the hippocampus with abnormal post-Golgi GABA receptor trafficking and localization
decreased miniature inhibitory postsynaptic current amplitude ( J:197666 )
• reduced mean amplitude with a shift to smaller amplitudes
• however, miniature inhibitory postsynaptic currents frequency, rise time and decay time are normal

growth/size/body
postnatal growth retardation ( J:197666 )

behavior/neurological
seizures ( J:197666 )
• mice exhibit epileptic electroencephalography (EEG) and reduced EEG power during rest and locomotive states compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory