Kif5a^tm1.1Noh
Targeted Allele Detail

Summary

• Symbol: Kif5a^tm1.1Noh
• Name: kinesin family member 5A; targeted mutation 1.1, Nobutaka Hirokawa
• MGI ID: MGI:5495649
• Gene: Kif5a Location: Chr10:127061565-127099217 bp, - strand Genetic Position: Chr10, 74.5 cM
• Alliance: Kif5a^tm1.1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197666
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed beta-geo (neomycin resistance and lacZ) cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the beta-geo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:197666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif5a Mutation: 55 strains or lines available

References

• Original: J:197666 Nakajima K, et al., Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Neuron. 2012 Dec 6;76(5):945-61
• All: 1 reference(s)