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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl3tm1.1Ljp
targeted mutation 1.1, Louis J Ptacek
MGI:5494565
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp Not Specified MGI:5494569
cx2
 		Cry2tm1Asn/Cry2tm1Asn
Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp 		involves: 129P2/OlaHsd MGI:5494571
cx3
 		Cry1tm1Asn/Cry1tm1Asn
Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp 		involves: 129P2/OlaHsd MGI:5494572
cx4
 		Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Nr1d1tm1Schb/Nr1d1tm1Schb 		involves: 129S2/SvPas MGI:5494570


Genotype
MGI:5494569
hm1
Allelic
Composition		 Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3tm1.1Ljp mutation (0 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:194250 )
• period is 27.6 hours and heterozygote period is 24.4 hours




Genotype
MGI:5494571
cx2
Allelic
Composition		 Cry2tm1Asn/Cry2tm1Asn
Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2tm1Asn mutation (1 available); any Cry2 mutation (43 available)
Fbxl3tm1.1Ljp mutation (0 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:194250 )
• activity period of 28.2 hours suggesting a lack of interaction between these two genes




Genotype
MGI:5494572
cx3
Allelic
Composition		 Cry1tm1Asn/Cry1tm1Asn
Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1tm1Asn mutation (1 available); any Cry1 mutation (39 available)
Fbxl3tm1.1Ljp mutation (0 available); any Fbxl3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior period ( J:194250 )
• activity period of 24.3 hours suggesting the period is partially dependent on an interaction between these two genes




Genotype
MGI:5494570
cx4
Allelic
Composition		 Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Nr1d1tm1Schb/Nr1d1tm1Schb
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3tm1.1Ljp mutation (0 available); any Fbxl3 mutation (44 available)
Nr1d1tm1Schb mutation (1 available); any Nr1d1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:194250 )
N
• circadian rhythm is near normal at 23.7 hours
abnormal circadian behavior period ( J:194250 )
• unstable onset of activity
• about 10% of double homozygotes become arrhythmic after 2-3 weeks of constant darkness




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory