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Allele Symbol Allele Name Allele ID |
Tg(Prnp)4053Sbp transgene insertion 4053, Stanley B Prusiner MGI:5491029 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants show increased susceptibility to developing scrapie following RML prion inoculation, with an average incubation time of 59 days compared to 138 days in controls and average death of 65 days versus 159 days in controls
• however, scrapie incubation times and time of death in mutants inoculated with RML prions is prolonged by about 10 days compared to single Tg(Prnp)4053Sbp mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice remain free of central nervous system (CNS) dysfunction for more than 600 days of age, however 6 of 20 mutants develop CNS dysfunction between 605 and 815 days of age
• no neuropathic evidence for prion disease is evident
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• mutants show increased susceptibility to developing scrapie following RML prion inoculation, with abbreviated incubation times (45 days vs. 138 days in controls) and earlier onset of death (58 days vs. 159 days) than controls
• however, brains of ill mutants inoculated with RML prions show reduced spongiform degeneration and reactive astrocytic gliosis compared to nontransgenic mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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