All Phenotypes Ntn4<tm1Wjbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntn4^tm1Wjbr
targeted mutation 1, William Brunken
MGI:5490629

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntn4^tm1Wjbr/Ntn4^tm1Wjbr	B6.129-Ntn4^tm1Wjbr	MGI:5490631
cx2	Ntn4^tm1Wjbr/Ntn4^tm1Wjbr Tg(Thy1-YFP)HJrs/0	B6.Cg-Ntn4^tm1Wjbr Tg(Thy1-YFP)HJrs	MGI:5490632

Allelic Composition	Ntn4^tm1Wjbr/Ntn4^tm1Wjbr
Genetic Background	B6.129-Ntn4^tm1Wjbr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntn4^tm1Wjbr mutation (0 available); any Ntn4 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:196758 )

N	• mice exhibit normal retinal structure, corneal thickness, retinal ganglion cell axon pathfinding and optic nerve diameter

abnormal retina vasculature morphology ( J:196758 )

• microvessel branching in the middle levels is increased compared to in wild-type mice

• however, branching at the surface of the retina is largely normal

abnormal eye physiology ( J:196758 )

• increased proliferation in the cornea

cardiovascular system

abnormal retina vasculature morphology ( J:196758 )

• microvessel branching in the middle levels is increased compared to in wild-type mice

• however, branching at the surface of the retina is largely normal

cellular

increased cell proliferation ( J:196758 )

• mice exhibit increased proliferation in the cornea compared with wild-type mice

Allelic Composition	Ntn4^tm1Wjbr/Ntn4^tm1Wjbr Tg(Thy1-YFP)HJrs/0
Genetic Background	B6.Cg-Ntn4^tm1Wjbr Tg(Thy1-YFP)HJrs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntn4^tm1Wjbr mutation (0 available); any Ntn4 mutation (58 available)
Tg(Thy1-YFP)HJrs mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon fasciculation ( J:196758 )

• retinal ganglion cell (RGC) axons sometimes exhibit defasciculation that forms a fork-like structures before reaching the optic nerve

• fascicles on RGC axons are smaller than in control mice

abnormal retina ganglion cell morphology ( J:196758 )

• retinal ganglion cell axons sometimes exhibit defasciculation that forms a fork-like structures before reaching the optic nerve