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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SqleSum3-Jus
suppressor of methyl CpG binding protein 2-1, 1 Monica J Justice
MGI:5489914
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SqleSum3-Jus/SqleSum3-Jus involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5499840
cx2
 		Mecp2tm1.1Bird/Y
SqleSum3-Jus/Sqle+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5499839


Genotype
MGI:5499840
hm1
Allelic
Composition		 SqleSum3-Jus/SqleSum3-Jus
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SqleSum3-Jus mutation (0 available); any Sqle mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:198551 )
• mice die before E8.5 with a phenotype consistent with that found in mice with mutations affecting cholesterol synthesis




Genotype
MGI:5499839
cx2
Allelic
Composition		 Mecp2tm1.1Bird/Y
SqleSum3-Jus/Sqle+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Bird mutation (1 available); any Mecp2 mutation (38 available)
SqleSum3-Jus mutation (0 available); any Sqle mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:198551 )
• lifespan in increased at least 3 weeks from the average 50% lethality time point of Mecp2tm1.1Bird hemizygotes

behavior/neurological
lethargy ( J:198551 )
• at 20 weeks but ameliorated compared to in Mecp2tm1.1Bird hemizygotes
decreased startle reflex ( J:198551 )
• as in Mecp2tm1.1Bird hemizygotes
limb grasping ( J:198551 )
• at 8 and 20 weeks but ameliorated compared to in Mecp2tm1.1Bird hemizygotes
tremors ( J:198551 )
• at 8 and 20 weeks but ameliorated compared to in Mecp2tm1.1Bird hemizygotes
impaired coordination ( J:198551 )
• ameliorated compared to in Mecp2tm1.1Bird hemizygotes
abnormal locomotor activation ( J:198551 )
• ameliorated compared to in Mecp2tm1.1Bird hemizygotes

craniofacial
malocclusion ( J:198551 )
• as in Mecp2tm1.1Bird hemizygotes

growth/size/body
malocclusion ( J:198551 )
• as in Mecp2tm1.1Bird hemizygotes
abnormal body weight ( J:198551 )
• at 8 and 20 weeks but ameliorated compared to in Mecp2tm1.1Bird hemizygotes

immune system
dermatitis ( J:198551 )
• unlike Mecp2tm1.1Bird hemizygotes

integument
dermatitis ( J:198551 )
• unlike Mecp2tm1.1Bird hemizygotes

respiratory system
increased pulmonary respiratory rate ( J:198551 )
• as in Mecp2tm1.1Bird hemizygotes

skeleton
malocclusion ( J:198551 )
• as in Mecp2tm1.1Bird hemizygotes




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory