Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Has2tm1.1Chg mutation
(0 available);
any
Has2 mutation
(35 available)
Has2tm1.2Chg mutation
(0 available);
any
Has2 mutation
(35 available)
Tg(Hoxb6-cre)#Mku mutation
(1 available)
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skeleton
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• severe cartilage reduction at P0
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• reduced chondrocyte differentiation
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• joint positioning defects at P0 indicated by prominent changes in phalangeal cartilage nodule organization
• the interphalangeal joints are shifted perpendicularly at P0
• ectopic joints along the digit rays
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limbs/digits/tail
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• impaired phalangeal mesenchymal condensation
• however, mesenchyme proliferation is normal
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• longitudinally oriented cavities that split proximal and medial phalanges
• digit defect in the forelimb is restricted to the posterior digits
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embryo
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• impaired phalangeal mesenchymal condensation
• however, mesenchyme proliferation is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Has2tm1.1Chg mutation
(0 available);
any
Has2 mutation
(35 available)
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mortality/aging
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• die within hours of birth due to respiratory and feeding difficulties
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craniofacial
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• at E14.5, hyaluronic acid is only sporadically present
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• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells
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• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells
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• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls
• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos
• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves
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• remain lateral to the tongue at P0
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• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
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• reduced vertical dimension of the oral-nasal cavity
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• tongue occupies the entire oral-nasal cavity at P0
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• appears wider at early E14.5
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skeleton
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• at E14.5, hyaluronic acid is only sporadically present
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• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells
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• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells
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digestive/alimentary system
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• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls
• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos
• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves
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• remain lateral to the tongue at P0
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• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
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• tongue occupies the entire oral-nasal cavity at P0
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• appears wider at early E14.5
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growth/size/body
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• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls
• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos
• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves
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• remain lateral to the tongue at P0
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• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls
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• reduced vertical dimension of the oral-nasal cavity
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• tongue occupies the entire oral-nasal cavity at P0
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• appears wider at early E14.5
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Analysis Tools