Phenotypes associated with this allele

• Allele Symbol: Dscam^3J
• Allele Name: 3 Jackson
• Allele ID: MGI:5488751
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dscam^3J/Dscam^3J	involves: BALB/c * C3H/HeSnSmn * C57BL/Ka	MGI:5488754

Genotype
MGI:5488754

hm1

• Allelic Composition: Dscam^3J/Dscam^3J
• Genetic Background: involves: BALB/c * C3H/HeSnSmn * C57BL/Ka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Large dome shaped head, muscle stiffness and enlarged central and lateral ventricles in Dscam^3J/Dscam^3J mice

vision/eye

abnormal amacrine cell morphology ( J:195831 )

• amacrine cells exhibit less extensive defects in spacing and arborization compared with Dscam^2J homozygotes

• bNOS+ amacrine cells are hypertrophied

abnormal retina ganglion cell morphology ( J:195831 )

• abnormal spacing and arborization

thick retina ganglion layer ( J:195831 )

• expanded

abnormal retina inner nuclear layer thickness ( J:195831 )

• expanded, but even lamination unlike in Dscam^2J homozygotes

thick retina inner plexiform layer ( J:195831 )

• expanded

retina hyperplasia ( J:195831 )

skeleton

domed cranium ( J:195831 )

kyphosis ( J:195831 )

muscle

muscle hypertonia ( J:195831 )

• muscle stiffness

craniofacial

domed cranium ( J:195831 )

nervous system

hydrocephaly ( J:195831 )

enlarged brain ventricles ( J:195831 )

• central and lateral ventricles

enlarged lateral ventricles ( J:195831 )

abnormal dopaminergic neuron morphology ( J:195831 )

• occasional loose fasciculation

abnormal neurite morphology ( J:195831 )

• neurite lamination defects

abnormal amacrine cell morphology ( J:195831 )

• amacrine cells exhibit less extensive defects in spacing and arborization compared with Dscam^2J homozygotes

• bNOS+ amacrine cells are hypertrophied

abnormal retina ganglion cell morphology ( J:195831 )

• abnormal spacing and arborization