Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1(cre)Shah mutation
(1 available);
any
Pgr mutation
(73 available)
Vmn2r53em1Ktou mutation
(0 available);
any
Vmn2r53 mutation
(53 available)
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behavior/neurological
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• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a first or second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to female and castrated male urine or mice, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1(cre)Shah mutation
(1 available);
any
Pgr mutation
(73 available)
Vmn2r53em1Ktou mutation
(0 available);
any
Vmn2r53 mutation
(53 available)
|
|
|
behavior/neurological
|
• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to the first intruder, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
|
Allelic Composition |
Pgrtm1.1(cre)Shah/?
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Genetic Background |
involves: 129S/SvEv * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1(cre)Shah mutation
(1 available);
any
Pgr mutation
(73 available)
|
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normal phenotype
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• animals are viable and fertile
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