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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LCR-HBA1,LCR-HBB*)1Tow
transgene insertion 1, Timothy Townes
MGI:5484766
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hbbd3th/Hbb+
Tg(LCR-HBA1,LCR-HBB*)1Tow/0 		involves: C57BL/6 * DBA/2J * SJL MGI:5510724


Genotype
MGI:5510724
cx1
Allelic
Composition		 Hbbd3th/Hbb+
Tg(LCR-HBA1,LCR-HBB*)1Tow/0
Genetic
Background		 involves: C57BL/6 * DBA/2J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbbd3th mutation (4 available); any Hbb mutation (47 available)
Tg(LCR-HBA1,LCR-HBB*)1Tow mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:127701 )
• spleen is 2-4 times larger than control
anemia ( J:127701 )
• mild anemia
decreased erythrocyte cell number ( J:127701 )
• decreased red blood cell counts
decreased hemoglobin content ( J:127701 )
• decreased hemoglobin concentration
anisopoikilocytosis ( J:127701 )
• 90% of deoxygenated cells exhibit sickled shapes as compared to 1% of the transgene only mice
• sickled erythrocytes have projections or spicules similar to human sickled cells
reticulocytosis ( J:127701 )
• elevated reticulocyte counts

immune system
enlarged spleen ( J:127701 )
• spleen is 2-4 times larger than control

growth/size/body
enlarged spleen ( J:127701 )
• spleen is 2-4 times larger than control

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
sickle cell anemia DOID:10923 OMIM:603903
 J:127701




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory