All Phenotypes Mc4r<tm2Lowl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mc4r^tm2Lowl
targeted mutation 2, Bradford B Lowell
MGI:5484615

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mc4r^tm2Lowl/Mc4r^tm2Lowl	involves: 129S4/SvJaeSor * 129S6/SvEvTac	MGI:5609683
cn2	Mc4r^tm2Lowl/Mc4r^tm2Lowl Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609590
cn3	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609673
cn4	Mc4r^tm2Lowl/Mc4r^tm2Lowl Chat^tm1(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5484737

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:216397 )

• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit increased fat mass

behavior/neurological

polyphagia ( J:216397 )

• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit hyperphagia

growth/size/body

increased body weight ( J:216397 )

• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit increased body weight gain

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl Tg(Sim1-cre)1Lowl/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (44 available)
Tg(Sim1-cre)1Lowl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:216397 )

• increase in fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (44 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:216397 )

• increased fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Allelic Composition	Mc4r^tm2Lowl/Mc4r^tm2Lowl Chat^tm1(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (8 available); any Gt(ROSA)26Sor mutation (1046 available)
Mc4r^tm2Lowl mutation (0 available); any Mc4r mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:193452 )

N	• biophysical properties of cholinergic neurons are normal

abnormal nervous system electrophysiology ( J:193452 )

• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons

• similar results with Mc4r agonist THIQ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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