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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mc4rtm2Lowl
targeted mutation 2, Bradford B Lowell
MGI:5484615
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mc4rtm2Lowl/Mc4rtm2Lowl involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:5609683
cn2
 		Mc4rtm2Lowl/Mc4rtm2Lowl
Tg(Sim1-cre)1Lowl/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5609590
cn3
 		Mc4rtm2Lowl/Mc4rtm2Lowl
Slc17a6tm2(cre)Lowl/Slc17a6+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5609673
cn4
 		Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NCr MGI:5484737


Genotype
MGI:5609683
cn1
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased total body fat amount ( J:216397 )
• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit increased fat mass

behavior/neurological
polyphagia ( J:216397 )
• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit hyperphagia

growth/size/body
increased body weight ( J:216397 )
• mice injected with an adenovirus expressing cre-recombinase into the paraventricular hypothalamus exhibit increased body weight gain




Genotype
MGI:5609590
cn2
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Tg(Sim1-cre)1Lowl/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased total body fat amount ( J:216397 )
• increase in fat mass

behavior/neurological

growth/size/body
obese ( J:216397 )
increased body length ( J:216397 )




Genotype
MGI:5609673
cn3
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
Slc17a6tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased total body fat amount ( J:216397 )
• increased fat mass

behavior/neurological

growth/size/body
obese ( J:216397 )
increased body length ( J:216397 )




Genotype
MGI:5484737
cn4
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (57 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:193452 )
N
• biophysical properties of cholinergic neurons are normal
abnormal nervous system electrophysiology ( J:193452 )
• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons
• similar results with Mc4r agonist THIQ




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory