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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sppl2atm1Dgen
targeted mutation 1, Deltagen
MGI:5484576
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sppl2atm1Dgen/Sppl2atm1Dgen B6.129P2-Sppl2atm1Dgen MGI:5484586
cx2
 		Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Dgen/Sppl2atm1Dgen 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:5484587


Genotype
MGI:5484586
hm1
Allelic
Composition		 Sppl2atm1Dgen/Sppl2atm1Dgen
Genetic
Background		 B6.129P2-Sppl2atm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2atm1Dgen mutation (0 available); any Sppl2a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:194595 )
• in the spleen
decreased IgA level ( J:194595 )
• prior to immunization
decreased IgG1 level ( J:194595 )
• prior to immunization
• decreased DNP-specific IgG1 after immunization
decreased IgG2b level ( J:194595 )
• prior to immunization
decreased IgG3 level ( J:194595 )
• prior to immunization
• anti-TNP IgM after immunization
decreased IgM level ( J:194595 )
• prior to immunization
• decreased DNP-specific IgM after immunization
• anti-TNP IgM after immunization

hematopoietic system
decreased B cell number ( J:194595 )
• in the spleen
decreased IgA level ( J:194595 )
• prior to immunization
decreased IgG1 level ( J:194595 )
• prior to immunization
• decreased DNP-specific IgG1 after immunization
decreased IgG2b level ( J:194595 )
• prior to immunization
decreased IgG3 level ( J:194595 )
• prior to immunization
• anti-TNP IgM after immunization
decreased IgM level ( J:194595 )
• prior to immunization
• decreased DNP-specific IgM after immunization
• anti-TNP IgM after immunization




Genotype
MGI:5484587
cx2
Allelic
Composition		 Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Dgen/Sppl2atm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Liz mutation (5 available); any Cd74 mutation (37 available)
Sppl2atm1Dgen mutation (0 available); any Sppl2a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194595 )
N
• mice exhibit normalized numbers of T2 B cells, marginal zone B cells and myeloid dendritic cells

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory