All Phenotypes Nhej1<tm1.1Ics> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nhej1^tm1.1Ics/Nhej1^tm1.1Ics	involves: 129 * C57BL/6	MGI:5475165
ht2	Nhej1^tm1.1Ics/Nhej1⁺	involves: 129 * C57BL/6	MGI:5475166
cx3	Nhej1^tm1.1Ics/Nhej1^tm1.1Ics Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6	MGI:5475167

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte apoptosis ( J:194422 )

abnormal T cell receptor V(D)J recombination ( J:194422 )

• 2-fold reduction in recombination activity in double negative thymocytes

• the frequency of distal Valpha segment is reduced while the usage of proximal segments is increased 3.2-fold

• usage of distal Valpha segments is reduced in the thymus and spleen

• usage of 5' Jalpha segments is increased

decreased lymphocyte cell number ( J:194422 )

• slightly in the thymus, spleen and lymph nodes

decreased thymocyte number ( J:194422 )

decreased NK T cell number ( J:194422 )

• invariant NK T cells

cellular

increased sensitivity to induced cell death ( J:194422 )

• in mouse embryonic fibroblasts treated with phleomycin

increased thymocyte apoptosis ( J:194422 )

hematopoietic system

increased thymocyte apoptosis ( J:194422 )

abnormal T cell receptor V(D)J recombination ( J:194422 )

• 2-fold reduction in recombination activity in double negative thymocytes

• the frequency of distal Valpha segment is reduced while the usage of proximal segments is increased 3.2-fold

• usage of distal Valpha segments is reduced in the thymus and spleen

• usage of 5' Jalpha segments is increased

decreased lymphocyte cell number ( J:194422 )

• slightly in the thymus, spleen and lymph nodes

decreased thymocyte number ( J:194422 )

decreased NK T cell number ( J:194422 )

• invariant NK T cells

endocrine/exocrine glands

increased thymocyte apoptosis ( J:194422 )

decreased thymocyte number ( J:194422 )

Allelic Composition	Nhej1^tm1.1Ics/Nhej1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhej1^tm1.1Ics mutation (0 available); any Nhej1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:194422 )

immune system

decreased thymocyte number ( J:194422 )

endocrine/exocrine glands

decreased thymocyte number ( J:194422 )

Allelic Composition	Nhej1^tm1.1Ics/Nhej1^tm1.1Ics Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhej1^tm1.1Ics mutation (0 available); any Nhej1 mutation (14 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte apoptosis ( J:194422 )

• compared with cells from Nhej1^tm1.1Ics homozygotes and heterozygotes

abnormal T cell receptor V(D)J recombination ( J:194422 )

• Jalpha and Valpha usage are partially normalized

decreased NK T cell number ( J:194422 )

• partially recovery of invariant NK T cell numbers compared to in Nhej1^tm1.1Ics homozygotes

cellular

decreased thymocyte apoptosis ( J:194422 )

• compared with cells from Nhej1^tm1.1Ics homozygotes and heterozygotes

hematopoietic system

decreased thymocyte apoptosis ( J:194422 )

• compared with cells from Nhej1^tm1.1Ics homozygotes and heterozygotes

abnormal T cell receptor V(D)J recombination ( J:194422 )

• Jalpha and Valpha usage are partially normalized

decreased NK T cell number ( J:194422 )

• partially recovery of invariant NK T cell numbers compared to in Nhej1^tm1.1Ics homozygotes

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:194422 )

• compared with cells from Nhej1^tm1.1Ics homozygotes and heterozygotes

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