Phenotypes associated with this allele

• Allele Symbol: Gpx7^tm1Whle
• Allele Name: targeted mutation 1, Wen-Hwa Lee
• Allele ID: MGI:5473571
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx7^tm1Whle/Gpx7^tm1Whle	involves: 129P2/OlaHsd * C57BL/6	MGI:5473577

Genotype
MGI:5473577

hm1

• Allelic Composition: Gpx7^tm1Whle/Gpx7^tm1Whle
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:193993 )

• median lifespan is 400 days compared with 760 days for wild-type mice

neoplasm

increased tumor incidence ( J:193993 )

• various malignant neoplasms in moribund mice

increased salivary gland tumor incidence ( J:193993 )

• in moribund mice

increased mammary adenocarcinoma incidence ( J:193993 )

• in moribund mice

increased leukemia incidence ( J:193993 )

• in moribund mice

increased lymphoma incidence ( J:193993 )

• in moribund mice

increased lung adenocarcinoma incidence ( J:193993 )

• in moribund mice

increased sarcoma incidence ( J:193993 )

• in moribund mice

immune system

enlarged spleen ( J:193993 )

• in moribund mice

abnormal humoral immune response ( J:193993 )

• kidney antibody deposition in moribund mice

increased anti-nuclear antigen antibody level ( J:193993 )

• in moribund mice

glomerulonephritis ( J:193993 )

• in moribund mice

cellular

increased cellular sensitivity to oxidative stress ( J:193993 )

• in mouse embryonic fibroblasts at 20% oxygen or following treatment with hydrogen peroxide or tunicamycin

increased cellular sensitivity to hydrogen peroxide ( J:193993 )

• in mouse embryonic fibroblasts

increased fibroblast apoptosis ( J:193993 )

• in mouse embryonic fibroblasts exposed to a misfolded protein

oxidative stress ( J:193993 )

• mouse embryonic cells accumulate reactive oxygen species and are sensitive to oxidative stress

cardiovascular system

enlarged heart ( J:193993 )

• in moribund mice

vascular inflammation ( J:193993 )

• in moribund mice

liver/biliary system

hepatic steatosis ( J:193993 )

• in moribund mice

renal/urinary system

glomerulonephritis ( J:193993 )

• in moribund mice

digestive/alimentary system

stomach mucosa hyperplasia ( J:193993 )

• gastric foveolar hyperplasia in moribund mice

increased salivary gland tumor incidence ( J:193993 )

• in moribund mice

hematopoietic system

enlarged spleen ( J:193993 )

• in moribund mice

growth/size/body

enlarged heart ( J:193993 )

• in moribund mice

enlarged spleen ( J:193993 )

• in moribund mice

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:193993 )

• in moribund mice

increased mammary adenocarcinoma incidence ( J:193993 )

• in moribund mice

integument

increased mammary adenocarcinoma incidence ( J:193993 )

• in moribund mice

respiratory system

increased lung adenocarcinoma incidence ( J:193993 )

• in moribund mice