Gpx7^tm1Whle
Targeted Allele Detail

Summary

• Symbol: Gpx7^tm1Whle
• Name: glutathione peroxidase 7; targeted mutation 1, Wen-Hwa Lee
• MGI ID: MGI:5473571
• Synonyms: NPGPx^-
• Gene: Gpx7 Location: Chr4:108257414-108263910 bp, - strand Genetic Position: Chr4, 50.5 cM
• Alliance: Gpx7^tm1Whle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193993
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:193993)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx7 Mutation: 12 strains or lines available

References

• Original: J:193993 Wei PC, et al., Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell. 2012 Dec 14;48(5):747-59
• All: 3 reference(s)