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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnai2tm2.1Lbi
targeted mutation 2.1, Lutz Birnbaumer
MGI:5471645
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+ 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 MGI:5471658
cn2
 		Gnai2tm2.1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+ 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 MGI:5471659
cn3
 		Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Tg(Myog-cre)1Eno/0 		involves: 129S/SvEv * C57BL/6 MGI:5471660
cn4
 		Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Tg(Cd4-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA MGI:5474625


Genotype
MGI:5471658
cn1
Allelic
Composition		 Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation (0 available); any Gnai2 mutation (54 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
Sox9tm3(cre)Crm mutation (1 available); any Sox9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rib fusion phenotype is enhanced in Gnai3tm1Lbi/Gnai3tm1Lbi mice by loss of Gnai2 in cartilage

skeleton
rib fusion ( J:193170 )
• rib fusions are more severe compared to mice homozygous for Gnai3tm1Lbi alone
lumbar vertebral fusion ( J:193170 )
• not noticeably more severe than in mice homozygous for Gnai3tm1Lbi alone




Genotype
MGI:5471659
cn2
Allelic
Composition		 Gnai2tm2.1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation (0 available); any Gnai2 mutation (54 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
Sox9tm3(cre)Crm mutation (1 available); any Sox9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:193170 )
• rib fusions are more severe compared to mice homozygous for Gnai3tm1Lbi alone




Genotype
MGI:5471660
cn3
Allelic
Composition		 Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation (0 available); any Gnai2 mutation (54 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rib fusion phenotype is enhanced in Gnai3tm1Lbi/Gnai3tm1Lbi mice by loss of Gnai2 in cartilage

skeleton
rib fusion ( J:193170 )
• rib fusions are similar in severity to mice homozygous for Gnai3tm1Lbi alone




Genotype
MGI:5474625
cn4
Allelic
Composition		 Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation (0 available); any Gnai2 mutation (54 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:194587 )
• lose significantly more weight following dextran sulfate sodium treatment compared to controls

neoplasm
increased incidence of tumors by chemical induction ( J:194587 )
• increased number of colon tumors in mice treated with azoxymethane followed by 3 cycles of dextran sulfate sodium administration compared to controls
• tumors are predominantly distributed in the distal colon and 80% of mice show rectal prolapse

hematopoietic system
decreased T-helper 17 cell number ( J:194587 )
• isolated splenic CD4+ T cells develop significantly fewer T-helper 17 cells under polarizing conditions

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:194587 )
• increased number of colon tumors in mice treated with azoxymethane followed by 3 cycles of dextran sulfate sodium administration compared to controls
• tumors are predominantly distributed in the distal colon and 80% of mice show rectal prolapse

immune system
increased susceptibility to induced colitis ( J:194587 )
• lose significantly more weight following dextran sulfate sodium treatment compared to controls
decreased T-helper 17 cell number ( J:194587 )
• isolated splenic CD4+ T cells develop significantly fewer T-helper 17 cells under polarizing conditions




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory