All Phenotypes Smdt1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smdt1⁺
wild type
MGI:5469185

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Smdt1^{tm1b(EUCOMM)Wtsi}/Smdt1⁺	C57BL/6N-Smdt1^{tm1b(EUCOMM)Wtsi}/Bay	MGI:6263525
ht2	Smdt1^em1Fink/Smdt1⁺	involves: C57BL/6J * CBA	MGI:6457372
cx3	Micu1^em#Fink/Micu1^em#Fink Smdt1^em1Fink/Smdt1⁺	involves: C57BL/6J * C57BL/6N * CBA	MGI:6457369
cx4	Micu1^em#Fink/Micu1^em#Fink Smdt1^em2Fink/Smdt1⁺	involves: C57BL/6J * C57BL/6N * CBA	MGI:6457370

Allelic Composition	Smdt1^{tm1b(EUCOMM)Wtsi}/Smdt1⁺
Genetic Background	C57BL/6N-Smdt1^{tm1b(EUCOMM)Wtsi}/Bay
Cell Lines	EPD0486_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smdt1^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Smdt1 mutation (10 available)

Data Sources

IMPC Data for Smdt1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

tremors ( J:211773 )

IMPC - BCM

decreased locomotor activity ( J:211773 )

IMPC - BCM

Allelic Composition	Smdt1^em1Fink/Smdt1⁺
Genetic Background	involves: C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smdt1^em1Fink mutation (0 available); any Smdt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:238984 )

N	• mitochondrial calcium uptake is normal

Allelic Composition	Micu1^em#Fink/Micu1^em#Fink Smdt1^em1Fink/Smdt1⁺
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Micu1^em#Fink mutation (0 available); any Micu1 mutation (43 available)
Smdt1^em1Fink mutation (0 available); any Smdt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:238984 )

N	• mice exhibit normal survival

cellular

abnormal mitochondrial physiology ( J:238984 )

• liver mitochondria exhibit slightly impaired calcium gate-keeping function with 2-fold higher rates of calcium uptake at low extra-mitochondrial calcium levels and reduced rates of calcium uptake at high calcium concentrations compared with control mice

• however, brain matrix calcium levels are normal

behavior/neurological

impaired coordination ( J:238984 )

• improved compared to Micu1^em#Fink homozygotes

decreased grip strength ( J:238984 )

• improved compared to Micu1^em#Fink homozygotes

immune system

decreased B cell number ( J:238984 )

• improved compared to Micu1^em#Fink homozygotes

growth/size/body

growth/size/body region phenotype ( J:238984 )

N	• mice exhibit normal body weight

hematopoietic system

decreased B cell number ( J:238984 )

• improved compared to Micu1^em#Fink homozygotes

muscle

muscle phenotype ( J:238984 )

N	• mice exhibit normal skeletal muscles

nervous system

nervous system phenotype ( J:238984 )

N	• mice exhibit normal cerebellar morphology

Allelic Composition	Micu1^em#Fink/Micu1^em#Fink Smdt1^em2Fink/Smdt1⁺
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Micu1^em#Fink mutation (0 available); any Micu1 mutation (43 available)
Smdt1^em2Fink mutation (0 available); any Smdt1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:238984 )

N	• mice exhibit normal survival

growth/size/body

growth/size/body region phenotype ( J:238984 )

N	• mice exhibit normal body weight

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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