Micu1^em#Fink
Endonuclease-mediated Allele Detail

Summary

• Symbol: Micu1^em#Fink
• Name: mitochondrial calcium uptake 1; endonuclease-mediated mutation #, Toren Finkel
• MGI ID: MGI:6158962
• Synonyms: MICU1 KO
• Gene: Micu1 Location: Chr10:59538385-59699956 bp, + strand Genetic Position: Chr10, 29.6 cM
• Alliance: Micu1^em#Fink page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 generated 4 different deletion alleles. The pound symbol (#) is used when alleles are pooled. Western blot analysis confirmed the absence of protein expression in mitochondria. (J:238984)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Micu1 Mutation: 43 strains or lines available

References

• Original: J:238984 Liu JC, et al., MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016 Aug 09;16(6):1561-73
• All: 1 reference(s)