All Phenotypes Tlr4<tm1Djh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr4^tm1Djh
targeted mutation 1, David J Hackam
MGI:5469002

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tlr4^tm1Djh/Tlr4^tm1Djh Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J * FVB/N * SJL	MGI:5520917

Allelic Composition	Tlr4^tm1Djh/Tlr4^tm1Djh Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4^tm1Djh mutation (0 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal bile salt level ( J:193668 )

• reduced in the ileal lumen and stool

decreased susceptibility to injury ( J:193668 )

• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa and minimal cytokine elevation compared with wild-type mice

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

cellular

abnormal intestinal goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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