All Phenotypes Tlr4<tm1Djh> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr4^tm1Djh
targeted mutation 1, David J Hackam
MGI:5469002

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tlr4^tm1Djh/Tlr4^tm1Djh Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J * FVB/N * SJL	MGI:5520917

Allelic Composition	Tlr4^tm1Djh/Tlr4^tm1Djh Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4^tm1Djh mutation (0 available); any Tlr4 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal bile salt level ( J:193668 )

• reduced in the ileal lumen and stool

decreased susceptibility to injury ( J:193668 )

• following induction of necrotizing enterocolitis, mice exhibit preservation of the small intestinal mucosa and minimal cytokine elevation compared with wild-type mice

digestive/alimentary system

abnormal intestine goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

cellular

abnormal intestine goblet cell morphology ( J:193668 )

• increased goblet-like cells, more apparent along the duodenum-jejunum-ileum axis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24