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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccnd3tm2.1Pisc
targeted mutation 2.1, Piotr Sicinski
MGI:5468337
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:5468353
cn2
 		Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5468354


Genotype
MGI:5468353
cn1
Allelic
Composition		 Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm2.1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:192032 )
• tamoxifen-treated mice exhibit no obvious abnormalities




Genotype
MGI:5468354
cn2
Allelic
Composition		 Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm2.1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:192032 )
• pIpC-treated mice phenocopy abnormalities observed in Ccnd3tm1Pisc homozygotes
small thymus ( J:192032 )
• in pIpC-treated mice
decreased erythrocyte cell number ( J:192032 )
• modest in pIpC-treated mice
decreased leukocyte cell number ( J:192032 )
• modest in pIpC-treated mice
decreased double-positive T cell number ( J:192032 )
• in the thymus of pIpC-treated mice
abnormal hematopoietic stem cell physiology ( J:192032 )
• hematopoietic progenitor cells transduced with a retrovirus encoding activated Notch1 and injected into irradiated C57BL/6 mice induce apoptosis in acute lymphoblastic leukemia cells following pIpC-treatment compared with control mice

immune system
small thymus ( J:192032 )
• in pIpC-treated mice
decreased leukocyte cell number ( J:192032 )
• modest in pIpC-treated mice
decreased double-positive T cell number ( J:192032 )
• in the thymus of pIpC-treated mice

endocrine/exocrine glands
small thymus ( J:192032 )
• in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory