Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk}
• Allele Name: targeted mutation 1, Bruce Conklin
• Allele ID: MGI:5468098
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk/Gt(ROSA)26Sor^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5468297
cx2	Gt(ROSA)26Sor^tm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk/Gt(ROSA)26Sor^+ Tg(Col1a1-tTA)139Niss/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5468298

Genotype
MGI:5468297

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:193162 )

N • whether treated with doxycycline or not, mice are viable

skeleton

abnormal bone ossification ( J:193162 )

• small increase in bone formation in the calvaria

• however, bone mineral density is normal

Genotype
MGI:5468298

cx2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk}/Gt(ROSA)26Sor⁺; Tg(Col1a1-tTA)139Niss/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

mortality/aging ( J:193162 )

N • mice not supplemented with doxycycline exhibit normal embryonic survival

skeleton

increased bone mineral density ( J:193162 )

• at 9 weeks