Tg(Col1a1-tTA)139Niss
Transgene Detail

Summary

• Symbol: Tg(Col1a1-tTA)139Niss
• Name: transgene insertion 139, Robert Nissenson
• MGI ID: MGI:3852099
• Synonyms: Col-I 2.3 (139), ColI(2.3)-tTA, Col I-2.3-tTA(139)
• Transgene: Tg(Col1a1-tTA)139Niss Location: unknown
• Alliance: Tg(Col1a1-tTA)139Niss page

Skeletal abnormalities in Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0 mice

Show the 5 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The tetracycline transactivator (tTA) coding sequence is driven by the 2.3-kb promoter from the mouse collagen, type 1, alpha 1 gene, which drives expression specifically in mature osteoblasts and osteocytes of long bones and calvariae. In the absence of tetracycline, expression of a second transgene whose promoter is regulated by the tet operator sequence (tetO) is induced; this induction is suppressed by tetracycline administration. (J:131737)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131737 Peng J, et al., Conditional expression of a gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar;149(3):1329-37
• All: 11 reference(s)