All Phenotypes Sirt2<tm1Gdon> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sirt2^tm1Gdon
targeted mutation 1, Gizem Donmez
MGI:5467245

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt2^tm1Gdon/Sirt2^tm1Gdon	involves: 129P2/OlaHsd * C57BL/6	MGI:5467289
cx2	Sirt2^tm1Gdon/Sirt2^tm1Gdon Tg(HDexon1)62Gpb/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5467291

Allelic Composition	Sirt2^tm1Gdon/Sirt2^tm1Gdon
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2^tm1Gdon mutation (0 available); any Sirt2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:193012 )

N	• normal grip strength and performance on a rotarod

nervous system

nervous system phenotype ( J:193012 )

N	• normal brain weight

Allelic Composition	Sirt2^tm1Gdon/Sirt2^tm1Gdon Tg(HDexon1)62Gpb/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2^tm1Gdon mutation (0 available); any Sirt2 mutation (25 available)
Tg(HDexon1)62Gpb mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:193012 )

• as in Tg(HDexon1)62Gpb mice

decreased grip strength ( J:193012 )

• as in Tg(HDexon1)62Gpb mice

nervous system

decreased brain weight ( J:193012 )

• as in Tg(HDexon1)62Gpb mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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