Sirt2^tm1Gdon
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1Gdon
• Name: sirtuin 2; targeted mutation 1, Gizem Donmez
• MGI ID: MGI:5467245
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1Gdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193012
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A puro cassette was inserted into exon 11. Western blot analysis confirmed the absence of all three protein isoforms in the brain. (J:193012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 25 strains or lines available

References

• Original: J:193012 Bobrowska A, et al., SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One. 2012;7(4):e34805
• All: 5 reference(s)