Phenotypes associated with this allele

• Allele Symbol: Vtcn1^tm1Xxz
• Allele Name: targeted mutation 1, Xingxing Zang
• Allele ID: MGI:5463743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vtcn1^tm1Xxz/Vtcn1^tm1Xxz	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:5463747

Genotype
MGI:5463747

hm1

• Allelic Composition: Vtcn1^tm1Xxz/Vtcn1^tm1Xxz
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:177612 )

• after adoptive transfer of diabetogenic T cells

immune system

increased CD4-positive, alpha-beta T cell number ( J:177612 )

• activated CD4 T cells in MOG peptide-treated mice

• after adoptive transfer of diabetogenic T cells

increased T-helper 1 cell number ( J:177612 )

• in MOG peptide-treated mice

increased T-helper 17 cell number ( J:177612 )

• in MOG peptide-treated mice

increased interleukin-17 secretion ( J:177612 )

• in pancreatic T cells after adoptive transfer of diabetogenic T cells

increased susceptibility to autoimmune diabetes ( J:177612 )

• after adoptive transfer of diabetogenic T cells, mice exhibit more aggressive disease progression with earlier onset, higher mean glucose measurement and earlier lethality compared with wild-type mice

• however, the frequency of regulatory T cells is normal

increased susceptibility to experimental autoimmune encephalomyelitis ( J:177612 )

• MOG peptide-treated mice exhibit exacerbated experimental autoimmune encephalomyelitis with increased clinical scores and absolute numbers of activated CD4 T cells, Th1 and Th17 cells

• however, the frequency of regulatory T cells is normal

homeostasis/metabolism

increased circulating glucose level ( J:177612 )

• after adoptive transfer of diabetogenic T cells

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:177612 )

• activated CD4 T cells in MOG peptide-treated mice

• after adoptive transfer of diabetogenic T cells

increased T-helper 1 cell number ( J:177612 )

• in MOG peptide-treated mice

increased T-helper 17 cell number ( J:177612 )

• in MOG peptide-treated mice