All Phenotypes Vps52<tm1.2Kab> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vps52^tm1.2Kab
targeted mutation 1.2, Kuniya Abe
MGI:5463590

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps52^tm1.2Kab/Vps52^tm1.2Kab	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	MGI:5464112
cn2	Vps52^tm1.1Kab/Vps52^tm1.2Kab Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL * C57BL/6 * CBA * DBA	MGI:5464113
cx3	Vps52^tm1.2Kab/t^w5 Vps52^t-w5	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA	MGI:5464110

Allelic Composition	Vps52^tm1.2Kab/Vps52^tm1.2Kab
Genetic Background	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:190873 )

• early embryonic lethality similar to mice homozygous for t^w5

Allelic Composition	Vps52^tm1.1Kab/Vps52^tm1.2Kab Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL * C57BL/6 * CBA * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Vps52^tm1.1Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:190873 )

embryo

abnormal vitelline vasculature morphology ( J:190873 )

• vascular congestion is detected in the yolk sac at E8.5

disorganized yolk sac vascular plexus ( J:190873 )

• severe disruption of normal vascular patterning during yolk sac vasculogenesis

abnormal embryonic tissue morphology ( J:190873 )

• at E9.5 the rostral half of the embryo is formed almost normally but development of the caudal half is retarded

cardiovascular system

abnormal vitelline vasculature morphology ( J:190873 )

• vascular congestion is detected in the yolk sac at E8.5

disorganized yolk sac vascular plexus ( J:190873 )

• severe disruption of normal vascular patterning during yolk sac vasculogenesis

Allelic Composition	Vps52^tm1.2Kab/t^w5 Vps52^t-w5
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• at E6.5 all embryos show embryonic ectoderm defects typical of mice homozygous for t^w5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23