All Phenotypes Zbtb46<tm2.1Mnz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbtb46^tm2.1Mnz
targeted mutation 2.1, Michel C Nussenzweig
MGI:5462199

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb46^tm2.1Mnz/Zbtb46^tm2.1Mnz	involves: C57BL/6	MGI:5462201

Allelic Composition	Zbtb46^tm2.1Mnz/Zbtb46^tm2.1Mnz
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb46^tm2.1Mnz mutation (0 available); any Zbtb46 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Enlarged skin draining lymph nodes and increased vasculature in axillary lymph nodes of Zbtb46^tm2.1Mnz/Zbtb46^tm2.1Mnz mice

immune system

abnormal dendritic cell morphology ( J:191314 )

• common DCs exhibit partial activation in the steady state compared with wild-type cells

decreased dendritic cell number ( J:191314 )

• of splenic CD4+ common DCs

increased dendritic cell number ( J:191314 )

• slight increase in migrating dendritic cell (DC) numbers in skin draining lymph nodes

• of splenic CD8+ common DCs

• however, mice exhibit normal numbers of DC progenitors and common DC progenitors in the bone marrow and total common DCs in the spleen and lymph nodes

enlarged lymph nodes ( J:191314 )

• of skin-draining lymph nodes with prominent blood vessels

lymph node hyperplasia ( J:191314 )

• of skin-draining lymph nodes with prominent blood vessels

abnormal lymphangiogenesis ( J:191314 )

• increased as determined by enlarge skin-draining lymph nodes with prominent blood vessels

hematopoietic system

abnormal dendritic cell morphology ( J:191314 )

• common DCs exhibit partial activation in the steady state compared with wild-type cells

decreased dendritic cell number ( J:191314 )

• of splenic CD4+ common DCs

increased dendritic cell number ( J:191314 )

• slight increase in migrating dendritic cell (DC) numbers in skin draining lymph nodes

• of splenic CD8+ common DCs

• however, mice exhibit normal numbers of DC progenitors and common DC progenitors in the bone marrow and total common DCs in the spleen and lymph nodes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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