Zbtb46tm2.1Mnz
Targeted Allele Detail
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Symbol: |
Zbtb46tm2.1Mnz |
Name: |
zinc finger and BTB domain containing 46; targeted mutation 2.1, Michel C Nussenzweig |
MGI ID: |
MGI:5462199 |
Synonyms: |
zDC- |
Gene: |
Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
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Alliance: |
Zbtb46tm2.1Mnz page
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Enlarged skin draining lymph nodes and increased vasculature in axillary lymph nodes of Zbtb46tm2.1Mnz/Zbtb46tm2.1Mnz mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:191314
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Parent Cell Line: |
CY2.4 (ES Cell)
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Strain of Origin: |
B6(Cg)-Tyrc-2J
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre-mediated recombination removed the floxed exon 2 cassette. Western blot analysis confirmed the absence of protein expression in classical dendritic cells.
(J:191314)
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Generation of the Zbtb46tm2.1Mnz allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zbtb46 Mutation: |
36 strains or lines available
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Original: |
J:191314 Meredith MM, et al., Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med. 2012 Aug 27;209(9):1583-93 |
All: |
1 reference(s) |
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