Phenotypes associated with this allele

• Allele Symbol: Oxsr1^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5462099
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oxsr1^tm1.1Arte/Oxsr1^tm1.1Arte	involves: 129S/SvEvBrd * C57BL/6J	MGI:5462117
ht2	Oxsr1^tm1.1Arte/Oxsr1^+	involves: 129S/SvEvBrd	MGI:5462192

Genotype
MGI:5462117

hm1

• Allelic Composition: Oxsr1^tm1.1Arte/Oxsr1^tm1.1Arte
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:191566 )

• fewer than expected mice are present at E17.5

prenatal lethality, complete penetrance ( J:191566 )

• no mice are born

Genotype
MGI:5462192

ht2

• Allelic Composition: Oxsr1^tm1.1Arte/Oxsr1⁺
• Genetic Background: involves: 129S/SvEvBrd

immune system

abnormal dendritic cell morphology ( J:191351 )

• dendritic cells treated with lipopolysaccharide (LPS) fail to exhibit an increase in forward scatter (a measure of cell volume) unlike wild-type cells

• following an ammonium pulse, dendritic cells exhibit increased sodium dependent recovery of cytosolic pH prior to but not after LPS treatment compared with wild-type cells

• after ammonium pulse, dendritic cells exhibit increased sodium/hydrogen exchanger activity compared with wild-type cells

• treatment of dendritic cells with LPS did not modify sodium/hydrogen exchanger activity unlike in wild-type cells

• following LPS treatment, sodium/hydrogen exchanger activity is lower compared with wild-type cells

• treatment of dendritic cells with t-butyl hydroperoxide (TBOOH) did not modify sodium/hydrogen exchanger activity unlike in wild-type cells

• following treatment with TBOOH, sodium/hydrogen exchanger activity in dendritic cells is lower than in wild-type cells

• however, dendritic cells exhibit decreased forward scatter following treatment with LPS and cariporide

abnormal dendritic cell physiology ( J:191351 )

• LPS-treated dendritic cell migration is less pronounced than for wild-type cells

• before LPS treatment, reactive oxygen species formation in dendritic cells is higher than in wild-type cells and is decreased by cariporide treatment unlike in wild-type cells

• LPS fails to enhance reactive oxygen species formation in dendritic cells unlike in wild-type cells

hematopoietic system

abnormal dendritic cell morphology ( J:191351 )

• dendritic cells treated with lipopolysaccharide (LPS) fail to exhibit an increase in forward scatter (a measure of cell volume) unlike wild-type cells

• following an ammonium pulse, dendritic cells exhibit increased sodium dependent recovery of cytosolic pH prior to but not after LPS treatment compared with wild-type cells

• after ammonium pulse, dendritic cells exhibit increased sodium/hydrogen exchanger activity compared with wild-type cells

• treatment of dendritic cells with LPS did not modify sodium/hydrogen exchanger activity unlike in wild-type cells

• following LPS treatment, sodium/hydrogen exchanger activity is lower compared with wild-type cells

• treatment of dendritic cells with t-butyl hydroperoxide (TBOOH) did not modify sodium/hydrogen exchanger activity unlike in wild-type cells

• following treatment with TBOOH, sodium/hydrogen exchanger activity in dendritic cells is lower than in wild-type cells

• however, dendritic cells exhibit decreased forward scatter following treatment with LPS and cariporide