About   Help   FAQ
Oxsr1tm1.1Arte
Targeted Allele Detail
Summary
Symbol: Oxsr1tm1.1Arte
Name: oxidative-stress responsive 1; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:5462099
Synonyms: OSR1185A
Gene: Oxsr1  Location: Chr9:119067498-119151493 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Oxsr1tm1.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:191566
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 6 was replaced with a modified exon 6 in which an A to G transition results in the amino acid substitution of alanine for threonine at position 185 (T185A). This mutation is designed to prevent activation by WNK isoforms. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 6. (J:191566)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxsr1 Mutation:  41 strains or lines available
References
Original:  J:191566 Rafiqi FH, et al., Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010 Feb;2(2):63-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory