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Targeted Allele Detail
Symbol: Oxsr1tm1.1Arte
Name: oxidative-stress responsive 1; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:5462099
Synonyms: OSR1185A
Gene: Oxsr1  Location: Chr9:119067498-119151493 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Oxsr1tm1.1Arte page
Germline Transmission:  Earliest citation of germline transmission: J:191566
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
Mutation detailsExon 6 was replaced with a modified exon 6 in which an A to G transition results in the amino acid substitution of alanine for threonine at position 185 (T185A). This mutation is designed to prevent activation by WNK isoforms. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 6. (J:191566)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxsr1 Mutation:  41 strains or lines available
Original:  J:191566 Rafiqi FH, et al., Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010 Feb;2(2):63-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory