All Phenotypes Trpc3<tm1.1Bmil> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trpc3^tm1.1Bmil
targeted mutation 1.1, Barbara A Miller
MGI:5461709

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil	involves: FVB/N	MGI:5461712
cx2	Trpc2^tm1Dlc/Trpc2^tm1Dlc Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil	involves: 129S1/Sv * FVB/N	MGI:5461713

Allelic Composition	Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc3^tm1.1Bmil mutation (0 available); any Trpc3 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:189490 )

N	• all hematopoietic parameters are normal

Allelic Composition	Trpc2^tm1Dlc/Trpc2^tm1Dlc Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2^tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)
Trpc3^tm1.1Bmil mutation (0 available); any Trpc3 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythroblast morphology ( J:189490 )

• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells

increased hematocrit ( J:189490 )

decreased mean corpuscular hemoglobin concentration ( J:189490 )

increased mean corpuscular volume ( J:189490 )

abnormal erythrocyte physiology ( J:189490 )

• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells

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