Trpc3^tm1.1Bmil
Targeted Allele Detail

Summary

• Symbol: Trpc3^tm1.1Bmil
• Name: transient receptor potential cation channel, subfamily C, member 3; targeted mutation 1.1, Barbara A Miller
• MGI ID: MGI:5461709
• Gene: Trpc3 Location: Chr3:36674626-36744276 bp, - strand Genetic Position: Chr3, 17.93 cM, cytoband B
• Alliance: Trpc3^tm1.1Bmil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. A floxed neomycin selection cassette was inserted downstream of exon 8. Cre-mediated recombination removed exon 7, exon 8 and the neo cassette. RT-PCR confirmed the absence of transcript expression in erythroblasts. (J:189490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpc3 Mutation: 58 strains or lines available

References

• Original: J:189490 Hirschler-Laszkiewicz I, et al., Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis. Exp Hematol. 2012 Jan;40(1):71-83
• All: 2 reference(s)