Phenotypes associated with this allele

• Allele Symbol: Myo6^chl
• Allele Name: charlie
• Allele ID: MGI:5449854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo6^chl/Myo6^chl	involves: C57BL/6JAnu	MGI:5511010

Genotype
MGI:5511010

hm1

• Allelic Composition: Myo6^chl/Myo6^chl
• Genetic Background: involves: C57BL/6JAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal outer hair cell kinocilium morphology ( J:196601 )

abnormal orientation of inner hair cell stereociliary bundles ( J:196601 )

• disorganized

decreased inner hair cell stereocilia number ( J:196601 )

abnormal orientation of outer hair cell stereociliary bundles ( J:196601 )

• disorganized

decreased outer hair cell stereocilia number ( J:196601 )

absent organ of Corti ( J:196601 )

• by 12 weeks in the apical, mid or basal cochlear turns

organ of Corti degeneration ( J:196601 )

• pronounced at 4 weeks in the basal cochlear turn

decreased vestibular hair cell number ( J:196601 )

abnormal vestibular hair cell stereociliary bundle morphology ( J:196601 )

• elongated and fused, lacking the staircase oganization

fused vestibular hair cell stereocilia ( J:196601 )

vestibular hair cell degeneration ( J:196601 )

• at P2, advanced by 8 weeks

increased or absent threshold for auditory brainstem response ( J:196601 )

• at 4 weeks

impaired hearing ( J:196601 )

• profound

deafness ( J:196601 )

abnormal vestibular system physiology ( J:196601 )

cardiovascular system

increased heart weight ( J:196601 )

cardiomyopathy ( J:196601 )

• hypertrophic cardiomyopathy indicated by increased heart weight

behavior/neurological

absent pinna reflex ( J:196601 )

muscle

cardiomyopathy ( J:196601 )

• hypertrophic cardiomyopathy indicated by increased heart weight

nervous system

abnormal outer hair cell kinocilium morphology ( J:196601 )

abnormal orientation of inner hair cell stereociliary bundles ( J:196601 )

• disorganized

decreased inner hair cell stereocilia number ( J:196601 )

abnormal orientation of outer hair cell stereociliary bundles ( J:196601 )

• disorganized

decreased outer hair cell stereocilia number ( J:196601 )

decreased vestibular hair cell number ( J:196601 )

abnormal vestibular hair cell stereociliary bundle morphology ( J:196601 )

• elongated and fused, lacking the staircase oganization

fused vestibular hair cell stereocilia ( J:196601 )

vestibular hair cell degeneration ( J:196601 )

• at P2, advanced by 8 weeks

cochlear ganglion degeneration ( J:196601 )

• pronounced at 4 weeks in the basal cochlear turn

cellular

abnormal outer hair cell kinocilium morphology ( J:196601 )

growth/size/body

increased heart weight ( J:196601 )