Myo6^chl
Chemically induced Allele Detail

Summary

• Symbol: Myo6^chl
• Name: myosin VI; charlie
• MGI ID: MGI:5449854
• Gene: Myo6 Location: Chr9:80072313-80219011 bp, + strand Genetic Position: Chr9, 43.98 cM
• Alliance: Myo6^chl page

Mutation origin

• Strain of Origin: C57BL/6JAnu

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A intronic point mutation 5 bp downstream of exon 5 that results in skipping of exon 5 and the introduction of a stop codon at position 95 of 1262 amino acids. QRT-PCR confirmed the absence of transcript expression in the brain.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo6 Mutation: 90 strains or lines available

References

• Original: J:196601 Williams LH, et al., Characterization of a novel ENU-generated myosin VI mutant mouse strain with congenital deafness and vestibular dysfunction. Hear Res. 2013 May;299:53-62
• All: 1 reference(s)