Phenotypes associated with this allele

• Allele Symbol: Fras1^tm1.2Pjsc
• Allele Name: targeted mutation 1.2, Peter J Scambler
• Allele ID: MGI:5449389
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fras1^tm1.2Pjsc/Fras1^tm1.2Pjsc	involves: C57BL/6 * FVB/N * SJL	MGI:5449397
ht2	Fras1^bl/Fras1^tm1.2Pjsc	involves: 101/H * C3H/HeH * C57BL/6 * FVB/N * SJL	MGI:5449398

Genotype
MGI:5449397

hm1

• Allelic Composition: Fras1^tm1.2Pjsc/Fras1^tm1.2Pjsc
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hemorrhagic blistering and absence of kidney in Fras1^tm1.2Pjsc/Fras1^tm1.2Pjsc mice

cardiovascular system

hemorrhage ( J:190659 )

• hemorrhagic skin blistering

integument

blistering ( J:190659 )

• hemorrhagic skin blistering

renal/urinary system

absent kidney ( J:190659 )

• bilateral

Genotype
MGI:5449398

ht2

• Allelic Composition: Fras1^bl/Fras1^tm1.2Pjsc
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * FVB/N * SJL

Renal glomerulus abnormalities in Fras1^bl/Fras1^tm1.2Pjsc mice

renal/urinary system

renal/urinary system phenotype ( J:190659 )

N • mice exhibit normal kidney size and shape

abnormal glomerular capsule space morphology ( J:190659 )

• contains red cells unlike in control mice

abnormal renal glomerulus morphology ( J:190659 )

• in 4 of 7 sets of kidneys, with some that are smaller and less mature than in control mice

abnormal glomerular capillary morphology ( J:190659 )

• smaller capillary loops than in control mice

abnormal glomerular mesangium morphology ( J:190659 )

• more prominent than in control mice

cortical renal glomerulopathies ( J:190659 )

• variable in severity and extent

glomerulosclerosis ( J:190659 )

• in 10% to 20%

integument

integument phenotype ( J:190659 )

N • mice do not exhibit skin lesions

cardiovascular system

abnormal glomerular capillary morphology ( J:190659 )

• smaller capillary loops than in control mice