Fras1^tm1.2Pjsc
Targeted Allele Detail

Summary

• Symbol: Fras1^tm1.2Pjsc
• Name: Fraser extracellular matrix complex subunit 1; targeted mutation 1.2, Peter J Scambler
• MGI ID: MGI:5449389
• Synonyms: Fras1^delta2
• Gene: Fras1 Location: Chr5:96521814-96932587 bp, + strand Genetic Position: Chr5, 47.29 cM
• Alliance: Fras1^tm1.2Pjsc page

Hemorrhagic blistering and absence of kidney in Fras1^tm1.2Pjsc/Fras1^tm1.2Pjsc mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190659
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Cre-mediated recombination removed exon 2 and the neo cassette. (J:190659)

Generation of the Fras1^tm1.1Pjsc and Fras1^tm1.2Pjsc alleles

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fras1 Mutation: 216 strains or lines available

References

• Original: J:190659 Pitera JE, et al., Generation of mice with a conditional null fraser syndrome 1 (Fras1) allele. Genesis. 2012 Dec;50(12):892-8
• All: 2 reference(s)