Phenotypes associated with this allele

• Allele Symbol: Ccdc88a^tm4.1Mat
• Allele Name: targeted mutation 4.1, Masahide Takahashi
• Allele ID: MGI:5449207
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccdc88a^tm4.1Mat/Ccdc88a^tm4.1Mat Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:5449208
cn2	Ccdc88a^tm4.1Mat/Ccdc88a^+ Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:5449209

Genotype
MGI:5449208

cn1

• Allelic Composition: Ccdc88a^tm4.1Mat/Ccdc88a^tm4.1Mat; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:190129 )

• no mice are successfully weaned

• start to die after P12 with none surviving past P29

growth/size/body

decreased body weight ( J:190129 )

• starting at P5

postnatal growth retardation ( J:190129 )

behavior/neurological

decreased locomotor activity ( J:190129 )

• inactive

nervous system

abnormal rostral migratory stream morphology ( J:190129 )

• wider at P21

abnormal dentate gyrus morphology ( J:190129 )

• increase in the width of the layer of DCX-positive neurons at P15

small olfactory bulb ( J:190129 )

Genotype
MGI:5449209

cn2

• Allelic Composition: Ccdc88a^tm4.1Mat/Ccdc88a⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

nervous system

small olfactory bulb ( J:190129 )

• not as severe as in homozygous mice