All Phenotypes Tg(Krt18-EGFP,-TAg121)36Ysng MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Krt18-EGFP,-TAg121)36Ysng
transgene insertion 36, Yurong Song
MGI:5449063

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Krt18-EGFP,-TAg121)36Ysng/0	involves: C57BL/6 * DBA/2	MGI:5617493
cn2	Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:5617494
cn3	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:5617496
cn4	Brca2^tm1Brn/Brca2^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:5617497
cn5	Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5617495
cn6	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:5617499

Allelic Composition	Tg(Krt18-EGFP,-TAg121)36Ysng/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:189304 )

• when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium

ovary hyperplasia ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction

increased ovary tumor incidence ( J:189304 )

• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

reproductive system

abnormal ovary morphology ( J:189304 )

• when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium

ovary hyperplasia ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction

increased ovary tumor incidence ( J:189304 )

• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

neoplasm

increased ovary tumor incidence ( J:189304 )

• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

growth/size/body

ovary hyperplasia ( J:189304 )

• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction

Allelic Composition	Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm2Tyj mutation (4 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (113 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm2Tyj mutation (4 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

increased metastatic potential ( J:189304 )

• distant metastases are seen in the pleura of 87.5%, in the lung of 83% and in the liver of 46% of mutants intrabursally injected with Ad-cre that develop stage IV disease

increased carcinoma incidence ( J:189304 )

• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

reproductive system

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

abnormal oviduct morphology ( J:189304 )

• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

• oviduct lesions are characterized by a glandular/acinar histology

homeostasis/metabolism

hemorrhagic ascites ( J:189304 )

• ovaries in intrabursally Ad-cre injected mice show hemorrhagic or serous ascites

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Brca2^tm1Brn/Brca2^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm2Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm2Tyj mutation (4 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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