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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Neu3tm1Yamk
targeted mutation 1, Kazunori Yamaguchi
MGI:5446783
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Neu3tm1Yamk/Neu3tm1Yamk B6.129-Neu3tm1Yamk MGI:5446786
hm2
 		Neu3tm1Yamk/Neu3tm1Yamk involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:5446787


Genotype
MGI:5446786
hm1
Allelic
Composition		 Neu3tm1Yamk/Neu3tm1Yamk
Genetic
Background		 B6.129-Neu3tm1Yamk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neu3tm1Yamk mutation (0 available); any Neu3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased incidence of chemically induced colon tumors in Neu3tm1Yamk/Neu3tm1Yamk mice

neoplasm
neoplasm ( J:189604 )
N
• mice exhibit normal AOM- or DMH-induced aberrant crypt foci
decreased incidence of tumors by chemical induction ( J:189604 )
• mice treated with azoxymethane (AZO) and dextran sodium sulfate (DSS) exhibit reduced colon carcinogenesis

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:189604 )
• mice treated with azoxymethane (AZO) and dextran sodium sulfate (DSS) exhibit reduced colon carcinogenesis




Genotype
MGI:5446787
hm2
Allelic
Composition		 Neu3tm1Yamk/Neu3tm1Yamk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neu3tm1Yamk mutation (0 available); any Neu3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:189604 )
• Background Sensitivity: mice exhibit no overt abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory