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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il22ra2tm2Vlcg
targeted mutation 2, Velocigene
MGI:5446694
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il22ra2tm2Vlcg/Il22ra2tm2Vlcg B6.Cg-Il22ra2tm2Vlcg MGI:5446696
cx2
 		Il22tm1Flv/Il22tm1Flv
Il22ra2tm2Vlcg/Il22ra2tm2Vlcg 		involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac MGI:5446697
cx3
 		ApcMin/Apc+
Il22ra2tm2Vlcg/Il22ra2tm2Vlcg 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5446699


Genotype
MGI:5446696
hm1
Allelic
Composition		 Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic
Background		 B6.Cg-Il22ra2tm2Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22ra2tm2Vlcg mutation (0 available); any Il22ra2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers are increased in a colitis associated colon cancer model
increased tumor growth/size ( J:189217 )
• tumor size is increased in a colitis associated colon cancer model
decreased tumor latency ( J:189217 )
• tumor development is strongly accelerated in a colitis associated colon cancer model

digestive/alimentary system
colitis ( J:189217 )
• epithelial cell proliferation remains induced on day 14 during DSS induced colitis

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers are increased in a colitis associated colon cancer model

immune system
colitis ( J:189217 )
• epithelial cell proliferation remains induced on day 14 during DSS induced colitis




Genotype
MGI:5446697
cx2
Allelic
Composition		 Il22tm1Flv/Il22tm1Flv
Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22ra2tm2Vlcg mutation (0 available); any Il22ra2 mutation (22 available)
Il22tm1Flv mutation (0 available); any Il22 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2tm2Vlcg alone but increased compared to wild-type controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:189217 )
• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2tm2Vlcg alone but increased compared to wild-type controls




Genotype
MGI:5446699
cx3
Allelic
Composition		 ApcMin/Apc+
Il22ra2tm2Vlcg/Il22ra2tm2Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Il22ra2tm2Vlcg mutation (0 available); any Il22ra2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:189217 )
• in the colon but not the small intestine compared to compared to mice heterozygous for ApcMin alone
increased tumor growth/size ( J:189217 )
• in the colon but not the small intestine compared to compared to mice heterozygous for ApcMin alone

digestive/alimentary system
increased intestinal adenoma incidence ( J:189217 )
• in the colon but not the small intestine compared to compared to mice heterozygous for ApcMin alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory