Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
Yap1tm1.1Eno mutation
(0 available);
any
Yap1 mutation
(37 available)
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mortality/aging
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• embryos are dead at E10.5
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cardiovascular system
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• abnormally thin myocardium
• ventricular myocyte number is significantly reduced
• cardiac looping and chamber formation are normal
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• slower heart beat at E9.5
• mice are normal at E8.5
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muscle
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• abnormally thin myocardium
• ventricular myocyte number is significantly reduced
• cardiac looping and chamber formation are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation
(3 available)
Wwtr1tm1.1Eno mutation
(0 available);
any
Wwtr1 mutation
(23 available)
Yap1tm1.1Eno mutation
(0 available);
any
Yap1 mutation
(37 available)
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Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice exhibit cardiac abnormalities and Wwtr1tm1.1Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 hearts show defects in proliferation and survival
mortality/aging
cardiovascular system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation
(3 available)
Wwtr1tm1.1Eno mutation
(0 available);
any
Wwtr1 mutation
(23 available)
Yap1tm1.1Eno mutation
(0 available);
any
Yap1 mutation
(37 available)
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Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice
mortality/aging
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• die by 10 days of age
• lethality is accelerated compared to mutant mice wild type for Wwtr1
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cardiovascular system
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• about a 60% decrease in the number of cardiomyocytes
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cellular
muscle
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• about a 60% decrease in the number of cardiomyocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation
(3 available)
Wwtr1tm1.1Eno mutation
(0 available);
any
Wwtr1 mutation
(23 available)
Yap1tm1.1Eno mutation
(0 available);
any
Yap1 mutation
(37 available)
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Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Eno/Yap1+ Tg(Myh6-cre)2182Mds/0 mice
mortality/aging
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• complete lethality by 33 weeks of age from heart failure
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cardiovascular system
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• grossly dilated at 30 weeks of age but seen as early as 8 days of age
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homeostasis/metabolism
muscle
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• grossly dilated at 30 weeks of age but seen as early as 8 days of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation
(3 available)
Yap1tm1.1Eno mutation
(0 available);
any
Yap1 mutation
(37 available)
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Lethal cardiomyopathy in Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice
mortality/aging
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• die between 11 and 20 weeks of age from heart failure
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cardiovascular system
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• develops by 9 weeks of age
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• mild dilation is seen at 6 weeks of age and becomes more pronounced at 12 weeks of age
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• develops in older mice with dilated cardiomyopathy
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• mild functional heart deficits by 6 weeks of age
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• develops by 9 weeks of age and worsens with age
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• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age
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• at 26 days after permanent ligation of the left anterior descending coronary artery at P2, mice display a gross deficiency of healthy myocardial tissue throughout the LV free wall and extensive fibrotic infarct zone unlike controls that have fully regenerated by this time
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behavior/neurological
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• become lethargic between 11 and 20 weeks of age
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respiratory system
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• develops between 11 and 20 weeks of age
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homeostasis/metabolism
muscle
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• develops by 9 weeks of age and worsens with age
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• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age
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Analysis Tools