Phenotypes associated with this allele

• Allele Symbol: Ccdc80^tm1Ftrm
• Allele Name: targeted mutation 1, Frederic Tremblay
• Allele ID: MGI:5445519
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc80^tm1Ftrm/Ccdc80^tm1Ftrm	C57BL/6-Ccdc80^tm1Ftrm	MGI:5445537

Genotype
MGI:5445537

hm1

• Allelic Composition: Ccdc80^tm1Ftrm/Ccdc80^tm1Ftrm
• Genetic Background: C57BL/6-Ccdc80^tm1Ftrm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:189183 )

N • mice exhibit normal insulin sensitivity

increased insulin secretion ( J:189183 )

• in mice fed a high fat diet under low and high glucose concentrations

increased circulating glucose level ( J:189183 )

• in mice fed a high fat diet towards the end of the study

decreased circulating insulin level ( J:189183 )

• upon glucose administration in mice fed a high fat diet

increased circulating leptin level ( J:189183 )

• in mice fed a high fat diet

increased circulating free fatty acids level ( J:189183 )

• of nonesterified fatty acids in mice fed a low or high fat diet

decreased oxygen consumption ( J:189183 )

• during the dark phase in mice fed a high fat diet under minimal disturbance

impaired glucose tolerance ( J:189183 )

• in mice fed a high fat diet

enhanced lipolysis ( J:189183 )

• cell-autonomous

behavior/neurological

abnormal food intake ( J:189183 )

• decreased meal duration in mice fed a high fat diet under minimal disturbance

• however, meal number and size are normal

increased food intake ( J:189183 )

• in mice fed a high fat diet under minimal disturbance

• however, food intake is normal under moderate disturbance

adipose tissue

increased total body fat amount ( J:189183 )

• in mice fed a high fat diet

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:189183 )

• in mice fed a high fat diet

increased insulin secretion ( J:189183 )

• in mice fed a high fat diet under low and high glucose concentrations

growth/size/body

increased susceptibility to weight gain ( J:189183 )

• in mice fed a high fat diet under minimal disturbance

• however, weight gain is normal under moderate disturbance