Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}
• Allele Name: targeted mutation 13, Klaus Rajewsky
• Allele ID: MGI:5444670
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor^+ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444673
cn2	Gt(ROSA)26Sor^tm7(Pik3ca*,-EGFP)Rsky/Gt(ROSA)26Sor^tm13(CAG-MYC,-CD2*)Rsky Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5463978

Genotype
MGI:5444673

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺; Myc^tm2Fwa/Myc^tm2Fwa; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:188564 )

N • enforced expression of human MYC rescues germinal center formation

Genotype
MGI:5463978

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:191824 )

• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

neoplasm

increased B cell derived lymphoma incidence ( J:191824 )

• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen