All Phenotypes Gt(ROSA)26Sor<tm13(CAG-MYC,-CD2*)Rsky> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}
targeted mutation 13, Klaus Rajewsky
MGI:5444670

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444673
cn2	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2)Rsky} Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5463978

Allelic Composition	Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myc^tm2Fwa mutation (2 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:188564 )

N	• enforced expression of human MYC rescues germinal center formation

Allelic Composition	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2)Rsky} Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:191824 )

• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

neoplasm

increased B cell derived lymphoma incidence ( J:191824 )

• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

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