All Phenotypes Sftpc<tm1(cre/ERT2,rtTA)Hap> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sftpc^{tm1(cre/ERT2,rtTA)Hap}
targeted mutation 2, Harold A Chapman
MGI:5444645

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}	involves: 129 * C57BL/6 * C57BL/6J	MGI:8405106
cn2	Met^tm1Sst/Met^tm1Sst Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:6197801
cn3	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N	MGI:8405105
cn4	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N	MGI:8405107

Allelic Composition	Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:376785 )

• mice exhibit alveolar simplification on P21

abnormal type II pneumocyte morphology ( J:376785 )

• alveolar 2 epithelial cells from tamoxifen-treated mice contain more mitochondria close to the cell surface than in controls

cellular

abnormal mitochondrial physiology ( J:376785 )

• maximal respiration capacity of alveolar 2 epithelial cells cell mitochondria is decreased and alveolar 2 epithelial cells show reduced glycolysis, glycolytic capacity, and glycolytic reserve, indicating mitochondrial dysfunction

• however, no differences in basal respiration are detected by oxygen consumption

Allelic Composition	Met^tm1Sst/Met^tm1Sst Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Met^tm1Sst mutation (1 available); any Met mutation (81 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:264185 )

• tamoxifen-treated mice show reduced density of alveoli

overexpanded pulmonary alveolus ( J:264185 )

• alveoli are enlarged in tamoxifen-treated mice

emphysema ( J:264185 )

• adult mice treated with tamoxifen exhibit enlargement of alveolar airspace and loss of alveolar density, indicating emphysematous changes

Allelic Composition	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Emc3 mutation (16 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:376785 )

N	• lung morphology is not altered in tamoxifen-treated mice

Allelic Composition	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Emc3 mutation (16 available)
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:376785 )

N	• tamoxifen-treated adult mice show restoration of the decreased maximal respiration capacity of alveolar 2 epithelial cells cell mitochondria and improved glycolytic capacity that is seen in single mutant Sftpc mice

enlarged alveolar lamellar bodies ( J:376785 )

• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells

respiratory system

respiratory system phenotype ( J:376785 )

N	• tamoxifen-treated mice show restoration of the lung morphology seen in single mutant Sftpc mice, with rescue of the alveolar simplification in neonatal mice and in adult tamoxifen-treated mice

enlarged alveolar lamellar bodies ( J:376785 )

• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells

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