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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1atm2.1Cpt
targeted mutation 2.1, Cox Terhorst
MGI:5444609
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sh2d1atm2.1Cpt/Y
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5444639
cn2
 		Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5444641


Genotype
MGI:5444639
cn1
Allelic
Composition		 Sh2d1atm2.1Cpt/Y
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Sh2d1atm2.1Cpt mutation (0 available); any Sh2d1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:189126 )
N
• tamoxifen-treated mice exhibit functionally active NK T cells
abnormal germinal center B cell physiology ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells from tamoxifen-treated mice fail to exhibit an increase in numbers unlike in wild-type mice
abnormal humoral immune response ( J:189126 )
• tamoxifen-treated mice exhibit reduced late primary antibody response on transfer of OT-II CD4+ T cells compared with wild-type
decreased IgG level ( J:189126 )
• following immunization with NP-KLH and alpha-GalCer, tamoxifen-treated mice exhibit reduced NP-specific IgG that is more severe than in Sh2d1atm1Cpt homozygotes
decreased IgM level ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, tamoxifen treated mice produce less anti-NP-IgM compared with wild-type mice

hematopoietic system
abnormal germinal center B cell physiology ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells from tamoxifen-treated mice fail to exhibit an increase in numbers unlike in wild-type mice
decreased IgG level ( J:189126 )
• following immunization with NP-KLH and alpha-GalCer, tamoxifen-treated mice exhibit reduced NP-specific IgG that is more severe than in Sh2d1atm1Cpt homozygotes
decreased IgM level ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, tamoxifen treated mice produce less anti-NP-IgM compared with wild-type mice




Genotype
MGI:5444641
cn2
Allelic
Composition		 Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Sh2d1atm2.1Cpt mutation (0 available); any Sh2d1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:189126 )
N
• tamoxifen-treated mice exhibit functionally active NK T cells
abnormal germinal center B cell physiology ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells from tamoxifen-treated mice fail to exhibit an increase in numbers unlike in wild-type mice
abnormal humoral immune response ( J:189126 )
• tamoxifen-treated mice exhibit reduced late primary antibody response on transfer of OT-II CD4+ T cells compared with wild-type
decreased IgG level ( J:189126 )
• following immunization with NP-KLH and alpha-GalCer, tamoxifen-treated mice exhibit reduced NP-specific IgG that is more severe than in Sh2d1atm1Cpt homozygotes
decreased IgM level ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, tamoxifen treated mice produce less anti-NP-IgM compared with wild-type mice

hematopoietic system
abnormal germinal center B cell physiology ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells from tamoxifen-treated mice fail to exhibit an increase in numbers unlike in wild-type mice
decreased IgG level ( J:189126 )
• following immunization with NP-KLH and alpha-GalCer, tamoxifen-treated mice exhibit reduced NP-specific IgG that is more severe than in Sh2d1atm1Cpt homozygotes
decreased IgM level ( J:189126 )
• following exposure to NP-KLH with alpha-GalCer, tamoxifen treated mice produce less anti-NP-IgM compared with wild-type mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory