Phenotypes associated with this allele

• Allele Symbol: Bbs12^tm1.1Vmar
• Allele Name: targeted mutation 1.1, Vincent Marion
• Allele ID: MGI:5444297
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bbs12^tm1.1Vmar/Bbs12^tm1.1Vmar	involves: 129S6/SvEvTac * C57BL/6	MGI:5444396

Genotype
MGI:5444396

hm1

• Allelic Composition: Bbs12^tm1.1Vmar/Bbs12^tm1.1Vmar
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:189019 )

• in mice fed a high fat diet

increased circulating glucose level ( J:189019 )

• in fasted mice fed a high fat diet

increased circulating leptin level ( J:189019 )

decreased circulating free fatty acids level ( J:189019 )

• prior to and following insulin injection

decreased circulating interleukin-6 level ( J:189019 )

• in mice fed a high fat diet

decreased circulating tumor necrosis factor level ( J:189019 )

• in mice fed standard chow or a high fat diet

increased insulin sensitivity ( J:189019 )

• in obese mice

increased circulating adiponectin level ( J:189019 )

cellular

increased adipocyte glucose uptake ( J:189019 )

• enhanced glucose absorption in adipocytes

adipose tissue

abnormal fat cell morphology ( J:189019 )

• visceral adipocytes exhibit heterogeneous size with a large portion of small cells together with larger ones compared with adipocytes from control mice

• mice exhibit more cells per unit square compared with control mice

increased fat cell size ( J:189019 )

increased epididymal fat pad weight ( J:189019 )

• 1.5 times

increased adipocyte glucose uptake ( J:189019 )

• enhanced glucose absorption in adipocytes

immune system

decreased circulating interleukin-6 level ( J:189019 )

• in mice fed a high fat diet

decreased circulating tumor necrosis factor level ( J:189019 )

• in mice fed standard chow or a high fat diet

decreased inflammatory response ( J:189019 )

• mice fed a high fat diet do not exhibit an increase in macrophage infiltration adipose tissue and proinflammatory cytokine profiles compared with wild-type mice

vision/eye

photoreceptor outer segment degeneration ( J:189019 )

• at 12 weeks

thin retina outer nuclear layer ( J:189019 )

• at 12 weeks

retina degeneration ( J:189019 )

• at 12 weeks

growth/size/body

decreased birth body size ( J:189019 )

obese ( J:189019 )

• at 12 weeks

increased susceptibility to diet-induced obesity ( J:189019 )

• in mice fed a high fat diet

behavior/neurological

abnormal eating behavior ( J:189019 )

• at 8 weeks

renal/urinary system

renal/urinary system phenotype ( J:189019 )

N • mice do not exhibit renal abnormalities at 16 weeks of age

nervous system

photoreceptor outer segment degeneration ( J:189019 )

• at 12 weeks

skeleton

abnormal bone marrow morphology ( J:189019 )

• contains a small number of mature adipocytes unlike in wild-type mice