Bbs12^tm1.1Vmar
Targeted Allele Detail

Summary

• Symbol: Bbs12^tm1.1Vmar
• Name: Bardet-Biedl syndrome 12; targeted mutation 1.1, Vincent Marion
• MGI ID: MGI:5444297
• Gene: Bbs12 Location: Chr3:37366703-37375602 bp, + strand Genetic Position: Chr3, 18.41 cM
• Alliance: Bbs12^tm1.1Vmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189019
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exon 2. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed in adipose tissue and kidney. (J:189019)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbs12 Mutation: 26 strains or lines available

References

• Original: J:189019 Marion V, et al., BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response. Cell Metab. 2012 Sep 5;16(3):363-77
• All: 3 reference(s)