Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation
(0 available);
any
Sec63 mutation
(40 available)
Tg(CAG-cre/Esr1*)1Lbe mutation
(0 available)
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mortality/aging
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• in mice treated with a high does tamoxifen induction regime
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liver/biliary system
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• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype
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growth/size/body
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• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1Som mutation
(0 available);
any
Pkd1 mutation
(153 available)
Sec63tm1Som mutation
(0 available);
any
Sec63 mutation
(40 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
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renal/urinary system
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• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
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• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
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• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
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• dilated to a lesser extent than collecting tubules
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cellular
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• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
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• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
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homeostasis/metabolism
growth/size/body
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• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm2Som mutation
(0 available);
any
Pkd2 mutation
(84 available)
Sec63tm1Som mutation
(0 available);
any
Sec63 mutation
(40 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
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renal/urinary system
homeostasis/metabolism
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation
(0 available);
any
Sec63 mutation
(40 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
Tg(Pkd1)248Som mutation
(0 available)
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renal/urinary system
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation
(0 available);
any
Sec63 mutation
(40 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
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mortality/aging
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• by P60 associated with kidney cysts
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renal/urinary system
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• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype
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• dilated to a lesser extent than collecting tubules
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homeostasis/metabolism
growth/size/body
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• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype
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